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Kod Augmentin s Amoxicillin + Clavulanate, klavulanska kiselina djeluje kao ireverzibilni inhibitor beta-laktamaza, što omogućuje amoksicilinu da zadrži baktericidni učinak. Zbog pretežno bubrežne eliminacije, u bolesnika s klirensom kreatinina ispod 30 mL/min potrebno je prilagoditi doziranje Augmentin. Službene “informacije o Augmentin” navode i povećan rizik od konvulzija pri visokim dozama u bubrežnih bolesnika. Kod dokazane alergije na peniciline, alternativa Augmentin obično se traži među cefalosporinima treće generacije, ali uz oprez zbog moguće unakrsne reaktivnosti. Zato se prije kupnje preporučuje provjeriti autorizaciju ljekarne, a ne oslanjati se samo na frazu “kupiti Augmentin online sigurno”.

Voor de behandeling van bacteriële infecties wordt vaak metronidazol voorgeschreven, dat uitstekend doordringt in anaerobe biofilms. Patiënten die Flagyl met Metronidazole gebruiken, moeten absoluut alcohol mijden vanwege een hevige fysieke ontregeling die op een kater lijkt. Flagyl tabletten zijn verkrijgbaar in doseringen van 250 mg en 500 mg en worden vaak bij Giardia-infecties ingezet. De huidige prijs van Flagyl schommelt rond de vijftien euro per kuur, maar verschilt per vergoedingsregeling. Interessant is dat metronidazol ook off-label wordt toegepast bij hardnekkige rosacea door de ontstekingsremmende eigenschappen.

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